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- Title
Prognostic impact of bone marrow karyotype in childhood acute lymphoblastic leukaemia: Swedish experiences 1986-91.
- Authors
Forestier, E; Gustafsson, G; Heideman, A; Heim, S; Hernell, O; Mitelman, F; Nordenson, I; Swolin, B; Söderhäll, S; von Heideman, A; Söderhäll, S
- Abstract
The prognostic value of cytogenetic classification in acute lymphoblastic leukaemia (ALL) was evaluated in Swedish children below 16 years of age (n = 372) diagnosed between 1986 and 1991. A bone marrow karyotype was obtained in 281 cases, of which 149 (53%) showed clonal abnormalities. Event-free survival (p-EFS) was 0.64-0.69 in patients with diploid and pseudodiploid karyotype. Patients with massive hyperdiploidy (> 50 chromosomes) had the best outcome (p-EFS = 0.76) and those with hypodiploidy (< 46 chromosomes) had the worst (p-EFS = 0.33). White blood cell count and age were the strongest predictors of outcome. The karyotype reached borderline significance. The diagnostic karyotype was also a predictor of outcome after relapse, with hyperdiploid patients doing better than the others. The presence of a structural chromosomal abnormality did not constitute a negative prognostic factor when intensive chemotherapy was given.
- Publication
Acta Paediatrica, 1997, Vol 86, Issue 8, p819
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/j.1651-2227.1997.tb08604.x