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- Title
Tertatolol Preserves Renal Perfusion in Patients with Arterial Hypertension after Head Injury.
- Authors
Leeman, Marc; Naeije, Robert; Degaute, Jean-Paul; Brackman, François; Thomas, Joss; Prost, Jean-François
- Abstract
Tertatolol is a noncardioselective β-adrenergic blocking agent without partial agonist activity. Its central and renal hemodynamic effects were compared to those of an equipotent dosage of propranolol in two groups of 10 patients each who developed arterial hypertension and a hyperdynamic circulatory state after head injury. After tertatolol, 5 mg orally, mean arterial blood pressure was unaffected, heart rate decreased by 22% (p < 0.01) and cardiac index by 24% (p < 0.01) while renal blood flow remained unchanged (-5%; not significant) so that the renal fraction of cardiac index was increased by 22% (p < 0.05). After propranolol, 160mg orally, mean arterial blood pressure was not modified, heart rate decreased by 12% (p < 0.01), cardiac index by 16% (p < 0.01) and renal blood flow by 17% (p < 0.01) so that the renal fraction of cardiac index remained unchanged (-3%; not significant). Tertatolol is a potent β-blocking agent comparable to propranolol apart from the fact that it preserves renal perfusion; this peculiar effect is related to a redistribution of the reduced cardiac output to the benefit of the kidney. Copyright © 1986 S. Karger AG, Basel
- Publication
American Journal of Nephrology, 1986, Vol 6, Issue S2, p36
- ISSN
0250-8095
- Publication type
Article
- DOI
10.1159/000167331