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- Title
Simplified Approach to Incorporating Glycemic Response Within a Continuous Insulin Infusion Algorithm to Improve the Incidence of Hypoglycemia in a Single Burn Center.
- Authors
Hendrix, Hayden A; Velamuri, Sai R; Sultan-Ali, Ibrahim; Arif, Faisal; Hickerson, William L; Hill, David M
- Abstract
Attaining adequate glycemic control in burn patients has been shown to reduce infection-related mortality. Previous internal evaluation of continuous insulin infusion (CII) use revealed a hypoglycemia rate of 0.6% and an average time within goal glycemic range (70-149 mg/dl) of 13.8 h/day. A new algorithm, designed to adjust dosage based on glycemic response, underwent six iterations over 2 years before the final version was implemented. The purpose of this retrospective study was to assess the post-implementation performance of the newly developed CII algorithm. The current study was powered to detect a 50% reduction in hypoglycemic events, as compared to a pre-implementation historical control. The cohort was 62% male with a mean age of 54.5 ± 17.4. Sixty-five percent had thermal injuries with a median 23.5 (11-45) %TBSA. There were no differences in demographics between groups. Among the 20 records reviewed, 5239 point-of-care glucose values were assessed. Post-implementation, hypoglycemia rates were significantly lower (0.6% vs 0.2%; P < .001). There was no difference in median blood glucose between groups (149.9 vs 146.5 mg/dl; P = .56). Time spent within goal glycemic range was not significantly different (13.8 vs 14.7 h/day; P = 0.23). There were no differences in infection, length of stay, or survival. The consolidation, education, and implementation of a single, dynamic CII algorithm reduced the incidence of hypoglycemia. The authors expect that education and diligence with follow-up glucose monitoring will further improve time within goal glycemic range by preventing rebound hyperglycemia.
- Subjects
BURNS &; scalds complications; BLOOD sugar analysis; INTRAVENOUS therapy; HYPOGLYCEMIC agents; RETROSPECTIVE studies; INSULIN; PATIENT monitoring; HYPOGLYCEMIA; BURN care units; ALGORITHMS; LONGITUDINAL method
- Publication
Journal of Burn Care & Research, 2020, Vol 41, Issue 4, p791
- ISSN
1559-047X
- Publication type
journal article
- DOI
10.1093/jbcr/iraa058