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- Title
Influence of the age of erythrocytes on their insulin receptors.
- Authors
Eng, John; Lee, Lilly; Yalow, Rosalyn S.; Eng, J; Lee, L; Yalow, R S
- Abstract
Specific binding of 125I-insulin to erythrocyte receptors increased linearly with reticulocyte count in routine blood specimens from hospitalized patients. Specific binding as high as 30-35% is observed in patients with reticulocyte counts in the range of 20-25% compared with 9.0 +/- 0.5% specific binding in healthy control subjects with normal reticulocyte counts. It is concluded that care must be exercised in interpreting elevations of specific 125I-insulin binding to erythrocyte receptors as due to specific disease processes without considering how the disease itself may alter mean erythrocyte age at the time of sampling.
- Publication
Diabetes, 1980, Vol 29, Issue 2, p164
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.29.2.164