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- Title
Synthesis of sulfonamides bearing 1,3,5-triarylpyrazoline and 4-thiazolidinone moieties as novel antimicrobial agents.
- Authors
THI-DAN THACH; THI TUONG-VI LE; HUU THIEN-AN NGUYEN; CHI-HIEN DANG; VAN-SU DANG; THANH-DANH NGUYEN
- Abstract
Two series of sulfonamides were synthesized from 4-hydrazinylbenzenesulfonamide as the key starting material. 1,3,5-Triarylpyrazoline sulfonamides (2a-i) were obtained by cyclocondensation of various chalcones in 53- -64% yields, while 4-thiazolidinone derivatives (4a-e) were synthesized by cyclocondensation between mercaptoacetic acid and different phenylhydrazones in 43-62% yields. The synthesized compounds were characterized based on FTIR, 1H-NMR, 13C-NMR and HRMS data. The sulfonamides were evaluated for their in vitro antimicrobial activities against four bacterial strains (E. coli, P. aeruginosa, B. subtillis and S aureus), two filamentous fungal strains (A. niger and F. oxysporum) and two yeast strains (C. albicans and S. cerevisiae). Seven pyrazolines, 2a-c and 2e-h, exhibited significant inhibition of different microbial strains. Among them, compound 2b displayed good antifungal activity against A. niger (MIC value at 12.5 µg mL-1) over the reference drug.
- Subjects
ANTI-infective agents; THIOGLYCOLIC acid; CHALCONE; SULFONAMIDES; CHALCONES
- Publication
Journal of the Serbian Chemical Society, 2020, Vol 85, Issue 2, p155
- ISSN
0352-5139
- Publication type
Article
- DOI
10.2298/JSC180621057T