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- Title
Brain Natriuretic Peptide and NT-proBNP Levels Reflect Pulmonary Artery Systolic Pressure in Trekkers at High Altitude.
- Authors
WOODS, D. R.; MELLOR, A.; BEGLEY, J.; STACEY, M.; O'HARA, J.; HAWKINS, A.; YARKER, J.; FOXEN, S.; SMITH, C.; BOOS, C.
- Abstract
Our objective was to evaluate the utility of the natriuretic peptides BNP (brain natriuretic peptide) and NT-proBNP as markers of pulmonary artery systolic pressure (PASP) in trekkers ascending to high altitude (HA). 20 participants had BNP and NTproBNP assayed and simultaneous echocardiographic assessment of PASP performed during a trek to 5150 m. PASP increased significantly (p=0.006) with ascent from 24±4 to 39±11 mm Hg at 5150 m. At 5150 m those with a PASP=40 mm Hg (n=8) (versus those with PASP<40 mm Hg) had higher post-exercise BNP (pg/ml): 54.5±36 vs. 13.4±17 (p=0.012). Their resting BNP at 5150 m was also higher: 57.3±43.4 vs. 12.6±13 (p=0.017). In those with a pathological (=400 pg/ml) rise in NT-proBNP at 5150 m (n=4) PASP was significantly higher: 45.9±7.5 vs. 32.2±6.2 mm Hg (p=0.015). BNP and NT-proBNP may reflect elevated PASP, a central feature of high altitude pulmonary oedema, at HA.
- Subjects
BRAIN natriuretic factor; PULMONARY artery; SYSTOLIC blood pressure; HIKERS; INFLUENCE of altitude; BIOMARKERS; ECHOCARDIOGRAPHY
- Publication
Physiological Research, 2013, Vol 62, Issue 6, p597
- ISSN
0862-8408
- Publication type
Article
- DOI
10.33549/physiolres.932544