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- Title
Efficacy of lisinopril in migraine prophylaxis – an open label study.
- Authors
Schuh-Hofer, S.; Flach, U.; Meisel, A.; Israel, H.; Reuter, U.; Arnold, G.
- Abstract
The ACE-inhibitor lisinopril has previously been shown to be effective in migraine prophylaxis at a daily dose of 20 mg. To test the effect of a low dose of lisinopril (5 mg daily) in migraine prevention, we performed an open label study in 21 migraineurs. The primary outcome measure was frequency of migraine attacks. Secondary efficacy measures were migraine hours, intake of acute migraine drugs, pain intensity and responder rate. Compared with baseline conditions, the attack frequency of migraine attacks was significantly reduced ( P < 0.0005). The number of acute migraine drugs dropped significantly ( P = 0.002). Three patients dropped out because of intolerable cough. Our study suggests that even low doses of lisinopril may be effective in migraine treatment. However, its use may be limited by intolerable side-effects.
- Subjects
ACE inhibitors; ANTIHYPERTENSIVE agents; DRUG efficacy; MIGRAINE; CLINICAL drug trials; DRUG side effects
- Publication
European Journal of Neurology, 2007, Vol 14, Issue 6, p701
- ISSN
1351-5101
- Publication type
Article
- DOI
10.1111/j.1468-1331.2007.01764.x