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- Title
Nitazoxanide inhibits osteosarcoma cells growth and metastasis by suppressing AKT/mTOR and Wnt/β-catenin signaling pathways.
- Authors
Ye, Caihong; Wei, Mengqi; Huang, Huakun; Wang, Yuping; Zhang, Lulu; Yang, Chunmei; Huang, Yanran; Luo, Jinyong
- Abstract
Nitazoxanide inhibits osteosarcoma cells growth and metastasis by suppressing AKT/mTOR and Wnt/ -catenin signaling pathways NTZ promotes apoptosis of OS cells Next, we sought to investigate whether OS cells apoptosis was affected by NTZ. NTZ inhibits OS cell growth and metastasis in vivo The above results have indicated that NTZ may inhibit OS cells growth and metastasis I in vitro i . Keywords: apoptosis; metastasis; osteosarcoma; proliferation; signaling pathways EN apoptosis metastasis osteosarcoma proliferation signaling pathways 929 943 15 09/13/22 20220901 NES 220901 Introduction Osteosarcoma (OS) is the most common primary tumor of bone, which predominantly affects adolescents, with a second smaller peak of incidence in elderly individual ([10]).
- Subjects
CELL growth; CELLULAR signal transduction; WNT signal transduction; POLY ADP ribose; WNT proteins; LABORATORY management; LIFE sciences; BCL-2 proteins
- Publication
Biological Chemistry, 2022, Vol 403, Issue 10, p929
- ISSN
1431-6730
- Publication type
Article
- DOI
10.1515/hsz-2022-0148