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- Title
Mifepristone- and misoprostol-induced mid-trimester termination of pregnancy: A review of 272 cases.
- Authors
Rose, Sally B.; Shand, Carol; Simmons, Ann
- Abstract
Background: Mifepristone became available in New Zealand in 2001, and was first used for second trimester terminations at the Level J Unit, Wellington Hospital. The protocol is based on that published by Ashok et al. in Aberdeen. 1 Aims: To describe the use of mifepristone prior to misoprostol induction of labour for mid-trimester termination and to compare outcomes with the published data. Methods: A retrospective audit of prospectively collected notes for 272 women presenting for mid-trimester termination of pregnancy in a hospital termination clinic. Data collection included age, ethnicity, previous pregnancies, gestational age, induction-to-abortion interval, analgesia, and complications. Data were entered into an Access database and imported into Excel and Epi Info for the computation of descriptive statistics. Results: Data on completed abortion were available for 271 women (one chose not to continue the abortion following mifepristone). The median time to abortion was 6 h, and mean number of doses of misoprostol was three. The proportion of women who aborted within 24 h was 95.9%. Immediate surgical evacuation of retained placenta was required in 22 women (8.1%). Heavy bleeding occurred in 22 women (8.1%), and seven required a transfusion (2.6%). The proportion of women who required parenteral narcotics was 78.2%. Conclusions: Outcomes for women in the present review were comparable with those for previous publications using the same regimen, with the exception of a higher transfusion rate. Our experience supports the finding that the use of mifepristone as pretreatment to misoprostol results in a shorter induction-to-delivery interval than the use of misoprostol alone as has been reported by other groups.
- Subjects
ABORTION; MIFEPRISTONE; SECOND trimester of pregnancy; BIRTH control; OBSTETRICS
- Publication
Australian & New Zealand Journal of Obstetrics & Gynaecology, 2006, Vol 46, Issue 6, p479
- ISSN
0004-8666
- Publication type
Article
- DOI
10.1111/j.1479-828X.2006.00646.x