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- Title
Impairment of cell-mediated immunity in Pseudomonas aeruginosa pyelonephritis: Lack of suppressor cell activity in vivo.
- Authors
Colizzi, V.; Campa, M.; Garzelli, C.; Toca, L.; Bevilacqua, G.; Falcone, G.
- Abstract
Bacterial pyelonephritis was induced in mice by direct microinoculation of Pseudomonas aeruginosa in the kidney. In the acute phase of P. aeruginosa pyelonephritis, a state of cell-mediated immunity impairment, evaluated both in vitro as lymphocyte reactivity to concanavalin A and in vivo as host versus graft reaction has been observed. Furthermore, delayed-type hypersensitivity to specific bacterial antigen has been detected only when the kidney infection was subsiding, i.e., 3 weeks after bacteria inoculation. When investigating the mechanism of such T-cell impairment, we were unable to transfer the immunodepression, suggesting that suppressor cells are not involved in vivo. The role of P. aeruginosa inhibition of cell-mediated immunity in the pyelonephritic host is discussed.
- Publication
Medical Microbiology & Immunology, 1982, Vol 171, Issue 3, p123
- ISSN
0300-8584
- Publication type
Article
- DOI
10.1007/BF02123620