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- Title
ImmuneDB: a system for the analysis and exploration of high-throughput adaptive immune receptor sequencing data.
- Authors
Rosenfeld, Aaron M.; Meng, Wenzhao; Prak, Eline T. Luning; Hershberg, Uri
- Abstract
Summary: As high-throughput sequencing of B cells becomes more common, the need for tools to analyze the large quantity of data also increases. This article introduces ImmuneDB, a system for analyzing vast amounts of heavy chain variable region sequences and exploring the resulting data. It can take as input raw FASTA/FASTQ data, identify genes, determine clones, construct lineages, as well as provide information such as selection pressure and mutation analysis. It uses an industry leading database, MySQL, to provide fast analysis and avoid the complexities of using error prone flat-files.
- Subjects
B cells; ANTIGEN presenting cells; IMMUNOGLOBULIN producing cells; GENETIC mutation; CLONING
- Publication
Bioinformatics, 2017, Vol 33, Issue 2, p292
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btw593