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- Title
Cellular phenotype database: a repository for systems microscopy data.
- Authors
Kirsanova, Catherine; Brazma, Alvis; Rustici, Gabriella; Sarkans, Ugis
- Abstract
Motivation: The Cellular Phenotype Database (CPD) is a repository for data derived from highthroughput systems microscopy studies. The aims of this resource are: (i) to provide easy access to cellular phenotype and molecular localization data for the broader research community; (ii) to facilitate integration of independent phenotypic studies by means of data aggregation techniques, including use of an ontology and (iii) to facilitate development of analytical methods in this field. Results: In this article we present CPD, its data structure and user interface, propose a minimal set of information describing RNA interference experiments, and suggest a generic schema for management and aggregation of outputs from phenotypic or molecular localization experiments. The database has a flexible structure for management of data from heterogeneous sources of systems microscopy experimental outputs generated by a variety of protocols and technologies and can be queried by gene, reagent, gene attribute, study keywords, phenotype or ontology terms.
- Subjects
PHENOTYPES; MICROSCOPY; RNA interference; GENETIC databases; CELL lines; GENE libraries
- Publication
Bioinformatics, 2015, Vol 31, Issue 16, p2736
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btv199