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- Title
Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants.
- Authors
Springer, David N.; Bauer, Michael; Medits, Iris; Camp, Jeremy V.; Aberle, Stephan W.; Burtscher, Clemens; Höltl, Eva; Weseslindtner, Lukas; Stiasny, Karin; Aberle, Judith H.
- Abstract
We report SARS-CoV-2 neutralizing antibody titers in sera of triple-vaccinated individuals who received a booster dose of an original monovalent or a bivalent BA.1- or BA.4/BA.5-adapted vaccine or had a breakthrough infection with Omicron variants BA.1, BA.2 or BA.4/BA.5. A bivalent BA.4/BA.5 booster or Omicron-breakthrough infection induced increased Omicron-neutralization titers compared with the monovalent booster. The XBB.1.5 variant effectively evaded neutralizing-antibody responses elicited by current vaccines and/or infection with previous variants.
- Subjects
SARS-CoV-2 Omicron variant; BOOSTER vaccines; BREAKTHROUGH infections; COVID-19; IMMUNOGLOBULINS; ANTIBODY titer
- Publication
NPJ Vaccines, 2023, Vol 8, Issue 1, p1
- ISSN
2059-0105
- Publication type
Article
- DOI
10.1038/s41541-023-00708-9