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- Title
Kindlin-2 regulates hepatic stellate cells activation and liver fibrogenesis.
- Authors
Yu, Jun; Hu, Yinan; Gao, Yi; Li, Qinghai; Zeng, Zhilin; Li, Yong; Chen, Huilong
- Abstract
Liver fibrosis, the common response associated with chronic liver diseases, ultimately leads to cirrhosis, a major public health problem worldwide. Activation of hepatic stellate cells (HSCs) by transforming growth factor (TGF)-β1 is a key step in liver fibrosis. Here we report that Kindlin-2 expression is elevated in the livers of mice with experimental liver fibrosis and also in the livers of patients with liver fibrosis. TGF-β1 increases Kindlin-2 expression in cultured HSCs in a p38 and ERK mitogen-activated protein kinase (MAPK)-dependent manner, partly. More importantly, Kindlin-2 deficiency significantly attenuated mouse liver fibrosis and HSC activation. Mechanistically, Kindlin-2 promotes TGF-β signaling through upregulation of Smad2 and Smad3 phosphorylation. Our work demonstrates an important role for Kindlin-2 in liver fibrosis, and inhibiting Kindlin-2 in the livers may represent a novel strategy to treat liver fibrosis.
- Publication
Cell Death Discovery, 2018, Vol 4, Issue 1, pN.PAG
- ISSN
2058-7716
- Publication type
Article
- DOI
10.1038/s41420-018-0095-9