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- Title
Cortical thickness analysis to detect progressive mild cognitive impairment: a reference to Alzheimer's disease.
- Authors
Julkunen V; Niskanen E; Muehlboeck S; Pihlajamäki M; Könönen M; Hallikainen M; Kivipelto M; Tervo S; Vanninen R; Evans A; Soininen H
- Abstract
Background/Aims: Mild cognitive impairment (MCI) is associated with an increased risk of Alzheimer's disease (AD). It would be advantageous to be able to distinguish the characteristics of those MCI patients with a high probability to progress to AD if one wishes to monitor the disease development and treatment. Methods: We assessed the baseline MRI and maximum of 7 years clinical follow-up data of 60 MCI subjects in order to examine differences in cortical thickness (CTH) between the progressive MCI (P-MCI) and stable MCI (S-MCI) subjects. CTH was measured using an automatic computational surface-based method. During the followup, 15 MCI subjects converted to AD on average 1.9 8 1.3 years after the baseline examination, while 45 MCI subjects remained stable. Results: The P-MCI group displayed significantly reduced CTH bilaterally in the superior and middle frontal, superior, middle and inferior temporal, fusiform and parahippocampal regions as well as the cingulate and retrosplenial cortices and also in the right precuneal and paracentral regions compared to S-MCI subjects. Conclusions: Analysis of CTH could be used in conjunction with neuropsychological testing to identify those subjects with imminent conversion from MCI to AD several years before dementia diagnosis.
- Publication
Dementia & Geriatric Cognitive Disorders, 2009, Vol 28, Issue 5, p404
- ISSN
1420-8008
- Publication type
Journal Article
- DOI
10.1159/000256274