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- Title
Cerebellar Atrophy in Human and Murine Succinic Semialdehyde Dehydrogenase Deficiency.
- Authors
Acosta, Maria T.; Munasinghe, Jeeva; Pearl, Phillip L.; Gupta, Maneesh; Finegersh, Andrey; Gibson, K. Michael; Theodore, William H.
- Abstract
Human succinic semialdehyde dehydrogenase deficiency, an autosomal recessive disorder of γ-aminobutyric acid (GABA) catabolism, was modeled by a murine model sharing the phenotype of ataxia and seizures. Magnetic resonance imaging (MRI) with volumetry was obtained on 7 patients versus controls, and MRI with stereology was derived in 3 murine genotypes: null, wild-type, and heterozygous mutants. All patients had T1 hypointensity and T2 hyperintensity in globus pallidus, and 5 also had similar changes in subthalamic and cerebellar dentate nuclei. There was a trend for patients to have a smaller cerebellar vermis. Homozygous null mice had significantly lower total brain and cerebellar volumes than wild-types and heterozygotes. Stereology confirmed cerebellar atrophy and was otherwise normal in multiple regions. Cerebellar volume loss is present in the murine disorder with a trend for cerebellar atrophy in patients. Reduced cerebellar volume can reflect neurodegeneration and may be related to the clinical manifestations.
- Subjects
ATROPHY; AMINOBUTYRIC acid; PHENOTYPES; ATAXIA; SPASMS; GENETIC carriers; STEREOLOGY; DIAGNOSIS
- Publication
Journal of Child Neurology, 2010, Vol 25, Issue 12, p1457
- ISSN
0883-0738
- Publication type
Article
- DOI
10.1177/0883073810368137