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- Title
Clinical potential of the Hippo-YAP pathway in bladder cancer.
- Authors
Xin Cheng; Kecheng Lou; Liang Ding; Xiaofeng Zou; Ruohui Huang; Gang Xu; Junrong Zou; Guoxi Zhang
- Abstract
Bladder cancer (BC) is one of the world's most frequent cancers. Surgery coupled with adjuvant platinum-based chemotherapy is the current standard of therapy for BC. However, a high proportion of patients progressed to chemotherapy-resistant or even neoplasm recurrence. Hence, identifying novel treatment targets is critical for clinical treatment. Current studies indicated that the Hippo-YAP pathway plays a crucial in regulating the survival of cancer stem cells (CSCs), which is related to the progression and reoccurrence of a variety of cancers. In this review, we summarize the evidence that Hippo-YAP mediates the occurrence, progression and chemotherapy resistance in BC, as well as the role of the Hippo-YAP pathway in regulating bladder cancer stem-like cells (BCSCs). Finally, the clinical potential of Hippo- YAP in the treatment of BC was prospected.
- Subjects
HIPPO signaling pathway; BLADDER cancer; CANCER stem cells; ADJUVANT chemotherapy; YAP signaling proteins
- Publication
Frontiers in Oncology, 2022, Vol 12, p1
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2022.925278