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- Title
A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID‐19 (SARS‐COV‐2) treatments.
- Authors
Baker, Emma H.; Gnjidic, Danijela; Kirkpatrick, Carl M.J.; Pirmohamed, Munir; Wright, Daniel F.B.; Zecharia, Anna Y.
- Abstract
The rapid emergence of coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to remarkable efforts by the scientific communities internationally to identify potential pharmacological treatments through the rapid initiation of clinical trials of novel and/or re-purposed regulatory authority-approved therapies. Further, I in vitro i efficacy does not guarantee that a drug will be efficacious and safe in humans using doses required to achieve free drug concentrations at the sites of infection, even for those agents already marketed for other indications. Drug development to treat COVID-19 has mainly focused on antivirals and immune modulators, with the logic that the early stages of the disease are characterised by the viral infection/replication stage, whereas the later, severe stage is characterised by the so-called "cytokine storm".
- Subjects
COVID-19; VIRAL shedding; PANDEMICS
- Publication
British Journal of Clinical Pharmacology, 2021, Vol 87, Issue 3, p707
- ISSN
0306-5251
- Publication type
Article
- DOI
10.1111/bcp.14416