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- Title
Activated hepatic stellate cells participate in liver fibrosis in a patient with transfusional iron overload.
- Authors
Harada, Yoshinori; Iwai, Masaki; Kakusui, Masamichi; Mori, Takahiro; Tada, Kazunobu; Ishii, Yasutaka; Okanoue, Takeshi; Kashima, Kei; Harada, Y; Iwai, M; Kakusui, M; Mori, T; Tada, K; Ishii, Y; Okanoue, T; Kashima, K
- Abstract
We describe liver fibrosis caused by iron overload after a long history of blood transfusion in a patient with chronic renal failure. Pertinent laboratory data were: serum (s)-Fe 148 microg/dl; unsaturated iron binding capacity (UIBC) 14 microg/dl; s-ferritin 9350 ng/ml; human leukocyte antigen (HLA) A2, A24, B39, B55, Cw1, Cw7. Computed tomography revealed a high density in the liver, and laparoscopy revealed a brown liver. Liver histology showed bridging fibrosis from portal tracts. A heavy iron deposit was seen in Kupffer cells as well as in hepatocytes surrounded by fibrosis around the portal tracts. Immunocytochemistry revealed alpha-smooth muscle actin in many stellate cells distributed along the fibrotic area, and electron microscopy revealed infiltrating myofibroblastic stellate cells coexisting with collagen fibers around degenerated hepatocytes containing iron deposits. The findings are consistent with the notion that stellate cells play an important role in liver fibrogenesis in both genetic and transfusional iron overload hemochromatosis.
- Subjects
LIVER; CHRONIC kidney failure; KUPFFER cells; BLOOD transfusion; BLOOD transfusion reaction; DIFFERENTIAL diagnosis; IRON in the body; CIRRHOSIS of the liver
- Publication
Journal of Gastroenterology, 1998, Vol 33, Issue 5, p751
- ISSN
0944-1174
- Publication type
journal article
- DOI
10.1007/s005350050168