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- Title
Palladium‐Catalyzed Asymmetric Trifluoromethylated Allylic Alkylation of N‐Substituted Glycine Ethyl Esters with α‐(Trifluoromethyl)alkenyl Acetates.
- Authors
Zhang, Shuaibo; Li, Dong; Wang, Bangzhong; Sun, Wuding; Ma, Haojun; Di, Kai; Sun, Luyang; Zhao, Jinfeng; Qu, Jingping; Zhou, Yuhan
- Abstract
An efficient strategy for asymmetric trifluoromethylated allylic alkylation of easily available N‐substituted glycine ethyl esters with α‐(trifluoromethyl)alkenyl acetates has been developed. Catalyzed by a [Pd(C3H5)Cl]2/(R)‐BINAP, various trifluoromethyl‐containing N‐substituted glycine ethyl ester derivatives are afforded with good yields and excellent enantioselectivities. The product can be readily converted into diverse fluoro‐substituted species, which shows the practicability of this method.
- Subjects
ALLYLIC alkylation; ACETATES; ETHYL esters; GLYCINE; ESTER derivatives
- Publication
European Journal of Organic Chemistry, 2023, Vol 26, Issue 36, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202300593