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- Title
Peripheral Routes to Neurodegeneration: Passing Through the Blood–Brain Barrier.
- Authors
Giannoni, Patrizia; Claeysen, Sylvie; Noe, Francesco; Marchi, Nicola
- Abstract
A bidirectional crosstalk between peripheral players of immunity and the central nervous system (CNS) exists. Hence, blood–brain barrier (BBB) breakdown is emerging as a participant mechanism of dysregulated peripheral–CNS interplay, promoting diseases. Here, we examine the implication of BBB damage in neurodegeneration, linking it to peripheral brain-directed autoantibodies and gut–brain axis mechanisms. As BBB breakdown is a factor contributing to, or even anticipating, neuronal dysfunction(s), we here identify contemporary pharmacological strategies that could be exploited to repair the BBB in disease conditions. Developing neurovascular, add on, therapeutic strategies may lead to a more efficacious pre-clinical to clinical transition with the goal of curbing the progression of neurodegeneration.
- Subjects
BLOOD-brain barrier; NEURODEGENERATION; CENTRAL nervous system
- Publication
Frontiers in Aging Neuroscience, 2020, p1
- ISSN
1663-4365
- Publication type
Article
- DOI
10.3389/fnagi.2020.00003