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- Title
Association of bone mineral density of the anterior cranial base, obesity, and spontaneous cerebrospinal fluid rhinorrhea.
- Authors
Low, Christopher M.; Kim, Dong Kun; Smith, Alyssa J.; Yin, Linda X.; Smith, Byron M.; Stokken, Janalee K.; O'Brien, Erin K.; Link, Michael J.; Van Gompel, Jamie J.; Choby, Garret
- Abstract
Keywords: anterior skull base; cerebrospinal fluid leak; radioanatomic study; bone mineral density EN anterior skull base cerebrospinal fluid leak radioanatomic study bone mineral density 804 806 3 03/25/21 20210401 NES 210401 Spontaneous cerebrospinal fluid rhinorrhea (SCSFR) is a distinct clinical entity in which the integrity of skull base has been breached, resulting in leakage of CSF into the nasal cavity.1,2 Although a number of potential contributing etiologies to SCSFR have been addressed,3 elevated intracranial pressure (ICP) is widely considered to be the strongest contributing factor.3-5 It has been hypothesized that chronic elevation of ICP transmits hydrostatic pressure against the cranial base, leading to defects in areas of thinner bone.6 To date, there has been minimal investigation into other factors that may predispose patients with elevated BMI and ICP to develop SCSFR. Anterior skull base thickness, dehiscence, and association with CSF leak The bone of the skull base was thinner in the CSF leak group compared with the matched control groups at each of the points of interest. Right: Sagittal image showing the measurement around the posterior table and planum sphenoidale. gl Results Patients' characteristics Eighty-one patients, including 30 CSF leak patients and 25 nonobese control patients and 26 obese control patients, participated in the study.
- Subjects
CEREBROSPINAL fluid rhinorrhea; BONE density; SKULL base; RHINORRHEA; INTRACRANIAL hypertension; ANATOMICAL planes
- Publication
International Forum of Allergy & Rhinology, 2021, Vol 11, Issue 4, p804
- ISSN
2042-6976
- Publication type
Article
- DOI
10.1002/alr.22717