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- Title
Acute hepatocellular and cholestatic injury during therapy with hydrochlorothiazide - clinicohistopathologic findings: a case report.
- Authors
Taglietti, Fabrizio; Nonno, Franca Del; Baiocchini, Andrea; Falasca, Laura; Pieri, Stefano; Capone, Alessandro; Grilli, Elisabetta; Chinello, Pierangelo; Petrosillo, Nicola; Del Nonno, Franca
- Abstract
<bold>Introduction: </bold>Hydrochlorothiazide and thiazide-like diuretics are considered first-line drugs for initial therapy in uncomplicated arterial hypertension. Acute cholecystitis is a well-known complication during treatment with thiazide, and these drugs are also reported to be followed by pronounced insulin resistance.<bold>Case Presentation: </bold>We describe a case of acute cholestatic hepatitis in a 68-year-old Caucasian man who was receiving olmesartan and hydrochlorothiazide for arterial hypertension. From the clinical and histologic findings, we diagnosed him as having hepatocellular-cholestatic injury and a disorder of glucose metabolism in the liver. To the best of our knowledge, no histopathologic description of hydrochlorothiazide hepatotoxicity has previously been documented in the literature.<bold>Conclusion: </bold>In the differential diagnosis of cholestatic hepatitis, clinicians should be aware of the possibility of liver damage in patients receiving hydrochlorothiazide therapy.
- Subjects
DIURETICS; HYPERTENSION; BLOOD circulation disorders; CHOLECYSTITIS; GALLBLADDER diseases
- Publication
Journal of Medical Case Reports, 2010, Vol 4, Issue 1, p1
- ISSN
1752-1947
- Publication type
journal article
- DOI
10.1186/1752-1947-4-332