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- Title
Magnetic resonance imaging of human endothelial progenitors reveals opposite effects on vascular and muscle regeneration into ischaemic tissues.
- Authors
Gianella, Anita; Guerrini, Uliano; Tilenni, Manuela; Sironi, Luigi; Milano, Giuseppina; Nobili, Elena; Vaga, Stefania; Capogrossi, Maurizio C.; Tremoli, Elena; Pesce, Maurizio
- Abstract
Aims: The assessment of progenitor cell survival and efficacy after transplantation is one of the major challenges in cardiovascular cell therapy. Translation of currently used imaging techniques to patients is not immediate. Possible options include iron oxide particle loading into cells to be tracked using magnetic resonance (MR) and by MR-based water diffusion anisotropy analysis. The aim of the present study was to assess, using these techniques, the localization and survival of human ‘early’ endothelial progenitor cells (EPCs) and their effects on vascular and skeletal muscle regeneration in a mouse model of hind limb ischaemia.
- Subjects
MAGNETIC resonance imaging; MAGNETIC resonance; CELLULAR therapy; ISCHEMIA; PATIENTS; ANISOTROPY
- Publication
Cardiovascular Research, 2010, Vol 85, Issue 3, p503
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1093/cvr/cvp325