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- Title
Aedes aegypti anti-salivary gland antibody concentration and dengue virus exposure history in healthy individuals living in an endemic area in Colombia.
- Authors
Londoño-Rentería, Berlin; Cardenas, Jenny C.; Giovanni, Jennifer E.; Cardenas, Lucio; Villamizar, Paloma; Rolon, Jennifer; Chisenhall, Daniel M.; Christofferson, Rebecca C.; Carvajal, Daisy J.; Pérez, Omar G.; Wesson, Dawn M.; Mores, Christopher N.
- Abstract
Introduction: Mosquito salivary proteins are able to induce an antibody response that reflects the level of human-vector contact. IgG antibodies against dengue virus (DENV-IgG) are indicators of previous exposure. The risk of DENV transmission is not only associated to mosquito, or dengue factors but also to socioeconomic factors that may play an important role in the disease epidemiology. Objective: To determine the effect of presence of Ae. aegypti mosquito stages in households and history of dengue exposure on vector-human contact determined by the level of anti-salivary protein antibodies in people living in a Colombian endemic area. Materials and methods: A pilot study of 58 households and 55 human subjects was conducted in Norte de Santander, Colombia. A questionnaire for socioeconomic factors was administered and houses were examined for the presence of Ae. aegypti aquatic stages. The level of DENV-IgG antibodies (DENV-IgG), in addition to IgG and IgM anti-Ae. aegypti salivary gland extract (SGE) antibodies (SGE-IgG, SGE-IgM) were evaluated by ELISA using blood collected in filter paper. Results: This study found a significant higher level of SGE-IgG antibodies in subjects living in houses with aquatic stages of Ae. aegypti. It also showed a higher concentration of SGE-IgG antibodies in people exposed to DENV and a positive correlation between IgM-SGE and IgG-DENV and a negative correlation with IgG-SGE. Conclusion: Anti-salivary proteins antibodies are consistent with the presence of Ae. aegypti aquatic stages inside houses and DENV-IgG antibodies concentrations.
- Subjects
COLOMBIA; SALIVARY proteins; IMMUNOGLOBULIN G; DENGUE; THERAPEUTICS; DENGUE viruses; AEDES aegypti
- Publication
Biomédica: Revista del Instituto Nacional de Salud, 2015, Vol 35, Issue 4, p2
- ISSN
0120-4157
- Publication type
Article