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- Title
Human epicardium: ultrastructural ancestry of mesothelium and mesenchymal cells.
- Authors
Gherghiceanu, Mihaela; Popescu, L. M.
- Abstract
The human sub-epicardial area contains an unexplored cellular population under a layer of mesothelial cells. Transmission electron microscopy revealed the existence of interstitial Cajal-like cells (ICLCs), isolated smooth muscle cells (iSMC) and mesenchymal cells besides other well-known cells. The presence of iSMC in the sub-epicardial space is quite unique and could explain why epicardial-derived cells isolated from human epicardium generate smooth muscle cells in culture. Mesenchymal cells, guided by ICLCs, were found migrating from sub-epicardial area in the mesothelial layer. These findings suggest that epithelial-mesenchymal transition is not a common process involved in cardiac regeneration in vivo.
- Subjects
MESOTHELIUM; MUSCLE cells; HEART cells; ELECTRON microscopy; METASTASIS; EPITHELIUM; CANCER of unknown primary origin; EMBRYOLOGY
- Publication
Journal of Cellular & Molecular Medicine, 2009, Vol 13, Issue 9a, p2949
- ISSN
1582-1838
- Publication type
Article
- DOI
10.1111/j.1582-4934.2009.00869.x