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- Title
The players on the γ-secretase team.
- Authors
Takashima, Akihiko; Shimojo, Masafumi; Wolozin, Benjamin
- Abstract
The article cites that the involvement of γ-secretase components in hyperphosphorylation of tau supports the hypothesis that mutations in presenilin-1 contribute to the formation of neurofibrillary tangles. Thus, the γ-secretase complex might be involved in protease activity, but may also act independently to induce tau pathology. Elucidating the functions of the γ-secretase complex could illuminate as much about the development of tau-associated pathology in Alzheimer disease.
- Subjects
PRESENILINS; NERVE fibers; GENETIC mutation; ALZHEIMER'S disease; PATHOLOGY
- Publication
Nature Medicine, 2006, Vol 12, Issue 7, p766
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm0706-766