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- Title
T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura.
- Authors
Olsson, Bob; Andersson, Per-Ola; Jer&nring;s, Margarreta; Jacobsson, Stefan; Carlsson, Björn; Carlsson, Lena M.S.; Wadenvik, Hans
- Abstract
Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3[sup +] T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.
- Subjects
PURPURA (Pathology); CELL-mediated cytotoxicity; T cells; GENE expression
- Publication
Nature Medicine, 2003, Vol 9, Issue 9, p1123
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm921