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- Title
Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations.
- Authors
Robinson, Harriet L.; Montefiori, David C.; Johnson, R. Paul; Manson, Kelledy H.; Kalish, Marcia L.; Lifson, Jeffrey D.; Rizvi, Tahir A.; Lu, Shan; Hu, Shiu-Lok; Mazzara, Gail P.; Panicali, Dennis L.; Herndon, James G.; Glickman, Rhona; Candido, Maria A.; Lydy, Shari L.; Wyand, Michael S.; McClure, Harold M.
- Abstract
Eight different protocols were compared for their ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA priming followed by recombinant fowl pox virus booster immunizations. This containment did not require neutralizing antibody and was active for a series of challenges ending with a highly virulent virus with a primary isolate envelope heterologous to the immunizing strain.
- Subjects
POXVIRUS diseases; DNA; IMMUNODEFICIENCY
- Publication
Nature Medicine, 1999, Vol 5, Issue 5, p526
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/8406