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- Title
Melanocortin 1 Receptor Function: Shifting Gears from Determining Skin and Nevus Phenotype to Fetal Growth.
- Authors
Gruis, Nelleke A; van Doorn, Remco
- Abstract
Variants in the MC1R gene influence skin pigmentation and thereby modulate risk of melanoma and basal and squamous cell carcinoma. In this issue, Kinsler et al. report an association between the MC1R genotype and the development of congenital melanocytic nevi. Further, higher birth weight was observed in carriers of MC1R variants, suggesting a role for the melanocortin network in fetal growth.
- Subjects
MELANOCORTIN receptors; HUMAN phenotype; FETAL development; HUMAN genetic variation; HUMAN skin color; MELANOMA; SQUAMOUS cell carcinoma; CANCER risk factors
- Publication
Journal of Investigative Dermatology, 2012, Vol 132, Issue 8, p1953
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.2012.216