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- Title
Foxp3+ Cells Control Th2 Responses in a Murine Model of Atopic Dermatitis.
- Authors
Fyhrquist, Nanna; Lehtimäki, Sari; Lahl, Katharina; Savinko, Terhi; Lappeteläinen, Anna-Mari; Sparwasser, Tim; Wolff, Henrik; Lauerma, Antti; Alenius, Harri
- Abstract
The role of Foxp3+ regulatory T (Treg) cells in atopic dermatitis (AD) is still unclear. In a murine AD model, the number of Foxp3+ cells increased in the allergen-exposed skin area and in the secondary lymphoid organs. Both Foxp3+ and Foxp3− IL-10+ T cells accumulated at the site of allergen exposure, and CD103+ effector/memory Foxp3+ Treg cells expanded gradually in the lymph nodes throughout the sensitization protocol. The depletion of Foxp3+ Treg cells led to significantly exacerbated skin inflammation, including increased recruitment of inflammatory cells and expression of T helper type 2 cytokines, as well as elevated serum IgE levels. The effect of depleting Treg cells during epicutaneous sensitization was mirrored off by a stronger inflammatory response also in the lungs following airway challenge. Thus, Treg cells have an important role in controlling AD-like inflammation and the transfer of allergic skin inflammation to the lungs.
- Subjects
T cells; ATOPIC dermatitis; ALLERGENS; LYMPH nodes; CYTOKINES; IMMUNE response
- Publication
Journal of Investigative Dermatology, 2012, Vol 132, Issue 6, p1672
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.2012.40