We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Decreased tryptophan and increased kynurenine levels in mastocytosis associated with digestive symptoms.
- Authors
Georgin‐Lavialle, S.; Launay, J.‐M.; Côté, F.; Soucié, E.; Soria, A.; Damaj, G.; Moura, D. S.; Canioni, D.; Hanssens, K.; Chandesris, M.‐O.; Barète, S.; Dubreuil, P.; Lortholary, O.; Hermine, O.; Sokol, H.
- Abstract
The main metabolism pathway of tryptophan is protein formation, but it can also be metabolized into serotonin and kynurenine. Indoleamine 2,3-dioxygenase ( IDO) is the enzyme that catalyzes the degradation of tryptophan into kynurenine. Mastocytosis is a heterogeneous disease characterized by mast cell accumulation in various tissues with 57% of patients having gastrointestinal involvement. We studied tryptophan metabolism in mastocytosis patients displaying or not gastrointestinal features and healthy subjects ( n = 26 in each group). Mastocytosis patients with digestive symptoms displayed significantly increased kynurenine level and IDO activity as compared to healthy controls and mastocytosis patients without digestive symptoms. This could be linked to mast cell-mediated digestive inflammation among patients with mastocytosis. This work is the first focusing on kynurenine pathway in a mast cell disease and could help to understand the pathogenesis of digestive features in mastocytosis as well as in other mast cell-mediated diseases.
- Subjects
MAST cell disease; KYNURENINE; DIGESTION; SEROTONIN; INFLAMMATION; INDOLEAMINE 2,3-dioxygenase; PROTEIN metabolism
- Publication
Allergy, 2016, Vol 71, Issue 3, p416
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.12802