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- Title
Benign paroxysmal torticollis, benign paroxysmal vertigo, and benign tonic upward gaze are not benign disorders.
- Authors
Humbertclaude, Véronique; Krams, Benjamin; Nogue, Erika; Nagot, Nicolas; Annequin, Daniel; Tourniaire, Barbara; Tournier‐Lasserve, Elisabeth; Riant, Florence; Roubertie, Agathe; Echenne, Bernard; Nguyen, Marie‐Ange; Doummar, Diane; Milh, Mathieu; Napuri, Silvia; Lion‐François, Laurence; Tardieu, Marc; Cheuret, Emmanuel; Spitz, Marie‐Aude; Saint Martin, Anne; Dubois, Fanny
- Abstract
<bold>Aim: </bold>Benign paroxysmal torticollis (BPT), benign paroxysmal vertigo (BPV), and benign tonic upward gaze (BTU) are characterized by transient and recurrent episodes of neurological manifestations. The purpose of this study was to analyse the clinical relationships between these syndromes, associated comorbidities, and genetic bases.<bold>Method: </bold>In this cross-sectional study, clinical data of patients with BPT, BPV, or BTU were collected with a focus on developmental achievements, learning abilities, and rehabilitation. Neuropsychological assessment and genetic testing were performed.<bold>Results: </bold>Fifty patients (median age at inclusion 6y) were enrolled. Psychomotor delay, abnormal neurological examination, and low or borderline IQ were found in 19%, 32%, and 26% of the patients respectively. Cognitive dysfunction was present in 27% of the patients. CACNA1A gene mutation was identified in eight families, and KCNA1 and FGF14 mutation in one family respectively. The identification of a CACNA1A mutation was significantly associated with BTU (p=0.03) and with cognitive dysfunction (p=0.01). Patients with BPV were less likely to have cognitive dysfunction.<bold>Interpretation: </bold>Children with BPT, BPV, or BTU are at high risk of impaired psychomotor and cognitive development. These syndromes should not be regarded as benign and should be considered as part of the spectrum of a neurodevelopmental disorder.<bold>What This Paper Adds Ok: </bold>Patients with benign paroxysmal torticollis (BPT), benign paroxysmal vertigo (BPV), and benign tonic upward gaze (BTU) have an increased risk of psychomotor delay. These patients also have an increased risk of abnormal neurological examination and cognitive dysfunction. Gene mutations, especially in CACNA1A, were identified in 21% of the families. BPT, BTU, and BPV should not be regarded as benign. BPT, BTU, and BPV should be considered as part of the spectrum of a neurodevelopmental disorder.
- Subjects
FRANCE; BENIGN paroxysmal positional vertigo; NEUROLOGICAL disorders; MEDICAL care; EPISODIC memory; GENETIC disorders; AGE factors in disease; CALCIUM; COMPARATIVE studies; EYE movement disorders; FAMILY health; GENETIC techniques; GROWTH factors; LEARNING disabilities; NEUROPSYCHOLOGICAL tests; GENETIC mutation; NEUROLOGIC examination; NONPARAMETRIC statistics; PSYCHOMOTOR disorders; RESEARCH funding; TORTICOLLIS; VERTIGO; GENETIC testing; CROSS-sectional method; RETROSPECTIVE studies
- Publication
Developmental Medicine & Child Neurology, 2018, Vol 60, Issue 12, p1256
- ISSN
0012-1622
- Publication type
journal article
- DOI
10.1111/dmcn.13935