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- Title
Antibiotic associated diarrhea in outpatient pediatric antibiotic therapy.
- Authors
Tanır Basaranoğlu, Sevgen; Karaaslan, Ayşe; Salı, Enes; Çiftçi, Ergin; Gayretli Aydın, Zeynep Gökçe; Aldemir Kocabaş, Bilge; Kaya, Cemil; Şen Bayturan, Semra; Kara, Soner Sertan; Yılmaz Çiftdoğan, Dilek; Çay, Ümmühan; Gundogdu Aktürk, Hacer; Çelik, Melda; Ozdemir, Halil; Somer, Ayper; Diri, Tijen; Yazar, Ahmet Sami; Sütçü, Murat; Tezer, Hasan; Karadag Oncel, Eda
- Abstract
Background: Antibiotic-associated diarrhea is one of the most frequent side effects of antimicrobial therapy. We assessed the epidemiological data of antibiotic-associated diarrhea in pediatric patients in our region. Methods: The prospective multi-center study included pediatric patients who were initiated an oral antibiotic course in outpatient clinics and followed in a well-established surveillance system. This follow-up system constituded inclusion of patient by the primary physician, supply of family follow-up charts to the family, passing the demographics and clinical information of patient to the Primary Investigator Centre, and a close telephone follow-up of patients for a period of eight weeks by the Primary Investigator Centre. Results: A result of 758 cases were recruited in the analysis which had a frequency of 10.4% antibiotic-associated diarrhea. Among the cases treated with amoxicillin-clavulanate 10.4%, and cephalosporins 14.4% presented with antibiotic-associated diarrhea. In the analysis of antibiotic-associated diarrhea occurrence according to different geographical regions of Turkey, antibiotic-associated diarrhea episodes differed significantly (p = 0.014), particularly higher in The Eastern Anatolia and Southeastern Anatolia. Though most commonly encountered with cephalosporin use, antibiotic-associated diarrhea is not a frequent side effect. Conclusion: This study on pediatric antibiotic-associated diarrhea displayed epidemiological data and the differences geographically in our region.
- Subjects
TURKEY; PEDIATRIC therapy; DIARRHEA; ANTIBIOTICS; CHILD patients
- Publication
BMC Pediatrics, 2023, Vol 23, Issue 1, p1
- ISSN
1471-2431
- Publication type
Article
- DOI
10.1186/s12887-023-03939-w