We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Independent associations of urinary albumin-to-creatinine ratio and serum cystatin C with carotid intima-media thickness in community-living Taiwanese adults.
- Authors
Liu, Chiu-Shong; Li, Chia-Ing; Guo, Yuh-Cherng; Lin, Chih-Hsueh; Lin, Wen-Yuan; Liu, Chung-Hsiang; Wang, Mu-Cyun; Yang, Chuan-Wei; Yang, Shing-Yu; Li, Tsai-Chung; Lin, Cheng-Chieh
- Abstract
<bold>Background: </bold>Renal function is a key factor of cardiovascular disease. Carotid intima-media thickness (IMT) has been widely used as a marker of early subclinical atherosclerosis. The determinants of cystatin C, a novel marker of renal function, have not been extensively studied in the Asian population. This study aimed to assess the determinants of cystatin C and explore whether carotid thickening was associated with urinary albumin-creatinine ratio and cystatin C in community-living Taiwanese adults.<bold>Methods: </bold>A cross-sectional study was conducted on participants from Taichung City, Taiwan. All the participants underwent carotid ultrasonography. Carotid IMT-mean and IMT-maximum were derived. Kidney biomarkers were measured on the basis of urinary albumin-to-creatinine ratio (ACR) and cystatin C. Multiple linear regression analysis was used.<bold>Results: </bold>A total of 1032 individuals were recruited, and 469 (45.44%) of them were men. An increased cystatin C level was significantly associated with older age, male gender, lack of physical activity, low HDL cholesterol, abdominal obesity, high hs-CRP, and high ACR. The multivariate-adjusted mean carotid IMT-mean and IMT-maximum values significantly increased by 80.49 and 195.23 μm for every one unit of increase in cystatin C level and by 0.07 and 0.14 μm for every one unit of increase in ACR, respectively (all p < 0.001 except ACR on IMT-maximum with p < 0.01). Lack of physical activity, low HDL, abdominal obesity, high hs-CRP, and high ACR were the determinants of cystatin C.<bold>Conclusion: </bold>Cystatin C and ACR were strongly and linearly associated with carotid thickening, a marker of subclinical atherosclerosis.
- Subjects
TAI-chung shih (Taiwan); TAIWAN; CAROTID intima-media thickness; ASIANS; MULTIPLE regression analysis; ADULTS; PHYSICAL activity
- Publication
BMC Nephrology, 2020, Vol 21, Issue 1, pN.PAG
- ISSN
1471-2369
- Publication type
journal article
- DOI
10.1186/s12882-020-02123-x