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- Title
DJ-1, a causative gene product of a familial form of Parkinson’s disease, is secreted through microdomains
- Authors
Tsuboi, Yumi; Munemoto, Haruko; Ishikawa, Shizuma; Matsumoto, Ken-ichi; Iguchi-Ariga, Sanae M.M.; Ariga, Hiroyoshi
- Abstract
Abstract: DJ-1 is secreted into the serum and plasma of patients with various diseases. In this study, DJ-1 was found to be secreted into culture media of various cells and the amount of wild-type DJ-1 secreted was two-fold greater than that of mutant DJ-1 of cysteine at 106 (C106). Furthermore, the oxidative status of more than 90% of the DJ-1 secreted from HeLa cells was SOH and SO2H forms of C106. A portion of DJ-1 in cells was localized in microdomains of the membrane. These findings suggest that DJ-1 is secreted through microdomains and that oxidation of DJ-1 at C106 facilitates the secretion.
- Subjects
PARKINSON'S disease; BIOLOGICAL transport; BLOOD plasma; CANCER cells
- Publication
FEBS Letters, 2008, Vol 582, Issue 17, p2643
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.06.043