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- Title
Danggui Buxue Tang – A Chinese herbal decoction activates the phosphorylations of extracellular signal-regulated kinase and estrogen receptor α in cultured MCF-7 cells
- Authors
Gao, Qiu T.; Choi, Roy C.Y.; Cheung, Anna W.H.; Zhu, Judy T.T.; Li, Jun; Chu, Glanice K.Y.; Duan, Ran; Cheung, Jerry K.H.; Jiang, Zhi Y.; Dong, Xiao B.; Zhao, Kui J.; Dong, Tina T.X.; Tsim, Karl W.K.
- Abstract
Abstract: Danggui Buxue Tang (DBT), a Chinese herbal decoction used to treat ailments in women, contains Radix Astragali (Huangqi; RA) and Radix Angelicae Sinensis (Danggui; RAS). The weight ratio of RA to RAS used in DBT must be 5:1 as stipulated as early as AD 1247; however, DBT’s mechanism of action has never been described. Here, the estrogenic effects of DBT were investigated by determining the phosphorylations of estrogen receptor α (ERα) and extracellular signal-regulated kinase 1/2 (Erk1/2) in cultured MCF-7 cells. The application of DBT triggered the phosphorylation of ERα and Erk1/2 in a time-dependent manner. In contrast to the effect of estrogen, DBT triggered ERα phosphorylation at both S118 and S167. This DBT-specific phosphorylation was not triggered by an extract of one of the individual herbs, or by mixing the extracts of RA and RAS. DBT-induced downstream signals are described here. These signals suggest the uniqueness of this Chinese herbal decoction that requires a well-defined formulation.
- Subjects
PHOSPHORYLATION; ESTROGEN; HERBS; CELLS
- Publication
FEBS Letters, 2007, Vol 581, Issue 2, p233
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2006.12.018