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- Title
Histone deacetylase inhibitor BL1521 induces a G1-phase arrest in neuroblastoma cells through altered expression of cell cycle proteins
- Authors
Ouwehand, Krista; de Ruijter, Annemieke J.M.; van Bree, Chris; Caron, Huib N.; van Kuilenburg, André B.P.
- Abstract
Abstract: Histone deacetylase inhibitors (HDACi) have been discovered as potential drugs for cancer treatment. The effect of BL1521, a novel HDACi, on the cell cycle distribution and the induction of apoptosis was investigated in a panel of MYCN single copy and MYCN amplified neuroblastoma cell lines. BL1521 arrested neuroblastoma cells in the G1 phase and induced up to 30% apoptosis. Downregulation of CDK4, upregulation of p21WAF1/CIP1 and an increase of hypophosphorylated retinoblastoma protein were observed, indicating a possible mechanism for the cell-cycle arrest. BL1521 also induced downregulation of p27, which may underlie the observed induction of apoptosis.
- Subjects
CANCER treatment; NEUROBLASTOMA; APOPTOSIS; CELL death
- Publication
FEBS Letters, 2005, Vol 579, Issue 6, p1523
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.01.058