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- Title
Plasmatic vitamin C in nontreated hepatitis C patients is negatively associated with aspartate aminotransferase.
- Authors
Souza dos Santos, Rosane M.; de Bem, Andreza F.; Colpo, Elisângela; Bertoncello, Iara; Nogueira, Cristina W.; Rocha, João B. T.
- Abstract
Objectives: To evaluate the possible relationship between aminotransferases levels and markers of oxidative stress in chronic hepatitis C patients. Design and methods: Patients without treatment for hepatitis were divided in to group I (15–39 U/L); group II (41–76 U/L) and group III (81–311 U/L) of activity alanine aminotransferase (ALT). Blood markers of oxidative stress [catalase (CAT), glutathione peroxidase (GPx), thiobarbituric acid-reactive species (TBARS), nonprotein and protein thiol (NP-SH and P-SH) groups and vitamin C] were determined. Results: P-SH and NP-SH levels, TBARS, GPx and CAT were not different between groups. Vitamin C was significantly decreased in groups II ( P=0.03) and III ( P=0.001) when compared with group I and correlated negatively with aspartate aminotransferase (AST; r=−0.29, P=0.042). Conclusion: Vitamin C levels were negatively associated with AST, suggesting that vitamin C could be an additional indicator of hepatitis C severity.
- Subjects
VITAMIN C; HEPATITIS C; PATIENTS; ASPARTATE aminotransferase; OXIDATIVE stress
- Publication
Liver International, 2008, Vol 28, Issue 1, p54
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/j.1478-3231.2007.01599.x