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- Title
Low fibrosis progression of recurrent hepatitis C in apolipoprotein E ℇ4 carriers: relationship with the blood lipid profile.
- Authors
Fabris, Carlo; Toniutto, Pierluigi; Bitetto, Davide; Minisini, Rosalba; Smirne, Carlo; Caldato, Maya; Pirisi, Mario
- Abstract
The histological outcome of chronic hepatitis C is better among carriers of the apolipoprotein E (ApoE) ℇ4 allele, for reasons unknown. The orthotopic liver transplantation (OLT) setting allows to separate the role played by liver-derived ApoE (graft) from ApoE of different origin (recipient). Patients and methods: Forty-six OLT recipients with recurrent hepatitis C were studied. Grafts and recipients were genotyped for ApoE. In a follow-up extending up to 4 years, the serum triglycerides-to-cholesterol ratio ( T/ C ratio) was measured 1 year after OLT, whereas fibrosis progression was assessed yearly and expressed as fibrosis units/month (FU/mo). Results: A T/ C ratio ≤0.75 was observed in 13/15 cases in which both donor and recipient were ℇ4 carriers, 10/19 cases in which ℇ4 alleles were of exclusive recipient's origin and 5/12 cases in which ℇ4 alleles were of exclusive donor's origin or absent ( P<0.02). One year after OLT, a fibrosis progression ≤0.100 FU/mo was associated with a low T/ C ratio (24/34 vs. 4/12, P<0.05). An Ishak staging score >2 was reached later by male recipients who were ℇ4 carriers ( P<0.002). Conclusions: Recipient's carriage of ApoE ℇ4 affects fibrosis progression of recurrent hepatitis C through gender-specific mechanisms, associated with a peculiar, ApoE-associated, lipid profile.
- Subjects
HEPATITIS C; APOLIPOPROTEIN E; LIVER transplantation; DISEASE relapse; FIBROSIS; BLOOD lipids
- Publication
Liver International, 2005, Vol 25, Issue 6, p1128
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/j.1478-3231.2005.01156.x