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- Title
sFlt‐1/PlGF ratio as a predictive and prognostic marker for preeclampsia.
- Authors
Jeon, Hae Rin; Jeong, Da Hoe; Lee, Jin Young; Woo, Eun Young; Shin, Gwi Taek; Kim, Suk‐Young
- Abstract
Objective: Preeclampsia is clinically unpredictable and associated with adverse outcomes. Pregnant women with suspected preeclampsia require intensive monitoring or hospitalization for elevated sFlt‐1 (soluble fms‐like tyrosine kinase‐1) to PlGF (placental growth factor) ratios before symptoms arise. We aimed to determine the sFlt‐1/PlGF ratio's usefulness in predicting adverse pregnancy outcomes in preeclampsia. Methods: From January 2017 to February 2019, we measured the sFlt‐1/PlGF ratio in 73 singleton pregnant women suspected of preeclampsia and classified them into three groups: low‐risk (sFlt‐1/PlGF ratio < 38, n = 19), intermediate (38 ≤ ratio < 85, n = 9), and high‐risk (ratio ≥ 85, n = 32). Results: Although the low‐ and high‐risk groups both experienced weight gain during pregnancy, their body mass index (BMI) differed after pregnancy (p = 0.004). The number of women who had been taking antihypertensive medications for chronic hypertension since early pregnancy was higher in the low‐risk group (31.6% vs. 22.2%, 6.7%). The gestational weeks at birth were lower in the high‐risk group compared to that of the low‐risk group (32.0 weeks vs. 35.79 weeks, p < 0.001). In the high‐risk group, the average neonatal weight was significantly lighter (p = 0.021), and the period of stay in the neonatal intensive care unit was longer than that in the low‐risk group (p = 0.003). Conclusion: The sFlt‐1/PlGF ratio is a useful indicator of preeclampsia severity and can be utilized as a prognostic marker.
- Subjects
RISK factors of preeclampsia; BIOMARKERS; PLACENTAL growth factor; ANTIHYPERTENSIVE agents; PREDICTIVE tests; PREMATURE infants; GESTATIONAL age; PREECLAMPSIA; RISK assessment; WEIGHT gain; SEVERITY of illness index; LOW birth weight; PROTEIN-tyrosine kinases; PREGNANCY complications; BIRTH weight; DISEASE risk factors
- Publication
Journal of Obstetrics & Gynaecology Research, 2021, Vol 47, Issue 7, p2318
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/jog.14815