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- Title
Colloid or crystalloid solution on maternal and neonatal hemodynamics for cesarean section: A meta-analysis of randomized controlled trials.
- Authors
Li, Le; Zhang, Yang; Tan, Ying; Xu, Shiyuan
- Abstract
Aim To compare the effect of colloid and crystalloid on maternal and neonatal hemodynamics in cesarean section. Material and Methods We searched MEDLINE ( Pub Med, 1966-2011), EMBASE (1974-2011), http://www.clinicaltrials.gov, the Cochrane Controlled Clinical Trials Register Database, Biosis Preview, and the Chinese Biomedical Database (1980-2011). Randomized controlled trials involving healthy term patients undergoing scheduled cesarean delivery that compared the effect of colloid and crystalloid on hypotension, need for vasopressors, cardiac output, neonatal outcomes, and other adverse effects were analyzed. Results Ten trials of 853 patients were eligible for analysis. When colloid was used, significantly fewer hypotensive events occurred (odds ratio [ OR] 3.21, 95% CI 2.15-4.53, number needed to treat = 4), less demand for vasopressors (standard mean difference [ SMD] 0.77, 95% CI 0.34-1.21) and improved cardiac output ( SMD −1.08, 95% CI −2.00 - −0.17). In subgroup analysis, the use of colloid reduced hypotensive events and adverse effects in Asian patients. Conclusion Colloid hydration should be considered first, especially in Asian patients, focusing on dosage and type of fluids. Preventive or therapeutic vasopressors may be required in a significant proportion of patients.
- Subjects
BLOOD plasma substitutes; CESAREAN section; COLLOIDS; CONFIDENCE intervals; EPIDEMIOLOGY; HEMODYNAMICS; MEDICAL information storage &; retrieval systems; MEDLINE; META-analysis; HEALTH outcome assessment; SYSTEMATIC reviews; DATA analysis; TREATMENT effectiveness
- Publication
Journal of Obstetrics & Gynaecology Research, 2013, Vol 39, Issue 5, p932
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/jog.12001