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- Title
Asymmetric Alkoxy‐ and Hydroxy‐Carbonylations of Functionalized Alkenes Assisted by β‐Carbonyl Groups.
- Authors
Ren, Xinyi; Wang, Zhen; Shen, Chaoren; Tian, Xinxin; Tang, Lin; Ji, Xiaolei; Dong, Kaiwu
- Abstract
As a fundamental type of carbonylation reaction, the alkoxy‐ and hydroxy‐carbonylation of unsaturated hydrocarbons constitutes one of the most important industrial applications of homogeneous catalysis. However, owing to the difficulties in controlling multi‐selectivities for asymmetric hydrocarbonylation of alkenes, this reaction is typically limited to vinylarenes and analogues. In this work, a highly efficient asymmetric alkoxy‐ and hydroxy‐carbonylation of β‐carbonyl functionalized alkenes was developed, providing practical and easy access to various densely functionalized chiral molecules with high optical purity from broadly available alkenes, CO, and nucleophiles (>90 examples, 84–99 % ee). This protocol features mild reaction conditions and a broad substrate scope, and the products can be readily transformed into a diverse array of chiral heterocycles. Control experiments revealed the key role of the β‐carbonyl group in determining the enantioselectivity and promoting the activity, which facilitates chiral induction by coordination to the transition metal as rationalized by DFT calculations. The strategy of utilizing an innate functional group as the directing group on the alkene substrate might find further applications in catalytic asymmetric hydrocarbonylation reactions.
- Subjects
ALKENES; ENANTIOMERIC purity; CARBONYLATION; HOMOGENEOUS catalysis; TRANSITION metals; FUNCTIONAL groups
- Publication
Angewandte Chemie, 2021, Vol 133, Issue 32, p17834
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202105977