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- Title
GLİAL TÜMÖR TEDAVİSİNDE TAMAMLAYICI HEDEF TEDAVİ: PROSTAT SPESİFİK MEMBRAN ANTİJEN (PSMA).
- Authors
OĞUZOĞLU, Ali Serdar; ŞENOL, Nilgün; YASAN, Hasan; YÜCEER, Ramazan Oğuz; GAZELOĞLU, Cengiz; ÇİRİŞ, İbrahim Metin
- Abstract
Objective Gliomas are the most common primary brain tumors with different grades. Especially in the high grade gliomas tumor angiogenesis is an essential component, and a valuable marker for the prognosis. In this stuıdy we aimed to evaluate the expression of prostate specific membrane antigen (PSMA) in glial tumors by im-munochemistry method to determine different targeted therapies. Material and Methods Overall 93 patients' specimens, including Grade II (n=22), Grade III (n=19), Grade IV (n=52) glial tumors, were evaluated for PSMA-antibody via immunohistochemical method. PSMA staining intensities in tumor tissue and tumor epithelium were analyzed. Vascular expression in tumoral and extratumoral stroma, and intensity score, according to PSMA expression, in tumoral epithelium were analyzed. Results In high grade gliomas, vascular PSMA staining percentage and vascular intensity score were significantly higher than low grade (p<0.05). In the epithelium of the tumors, although a significant increase was observed in vascular PSMA staining percentage (p<0.05) of low grade tumors, the increase in vascular intensity score of high grade tumors was not significant. Conclusion Significant increase in PSMA staining percentage and vascular intensity score of tumor stroma in high grade gliomas due to more neovascularisation, demonstrates that therapeutic agents can be effective in this group of tumors.
- Publication
Medical Journal of Suleyman Demirel University, 2022, Vol 29, Issue 1, p133
- ISSN
1300-7416
- Publication type
Article
- DOI
10.17343/sdutfd.1066328