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- Title
Clinical utility of bioelectrical impedance analysis in patients with locoregional muscle invasive or metastatic urothelial carcinoma: a subanalysis of changes in body composition during neoadjuvant systemic chemotherapy.
- Authors
Miyake, Makito; Owari, Takuya; Iwamoto, Takashi; Morizawa, Yosuke; Hori, Shunta; Iida, Kota; Ohnishi, Kenta; Gotoh, Daisuke; Tatsumi, Yoshihiro; Nakai, Yasushi; Inoue, Takeshi; Anai, Satoshi; Torimoto, Kazumasa; Aoki, Katsuya; Yoneda, Tatsuo; Tanaka, Nobumichi; Fujimoto, Kiyohide; Marugami, Nagaaki; Shimada, Keiji
- Abstract
<bold>Purpose: </bold>The aim of this study was to determine the clinical utility of bioelectrical impedance analysis (BIA) in a cohort of patients with advanced urothelial carcinoma (UC).<bold>Methods: </bold>We prospectively evaluated body composition in 35 patients with locoregional muscle invasive (≥ T2 and N0-2M0) or metastatic UC. Body composition was evaluated using multifrequency BIA at baseline (n = 35) and during chemotherapy in patients receiving neoadjuvant chemotherapy (n = 14). The BIA-predicted body composition index was compared with the computed tomography-measured muscle index and the prognostic nutrition index. Changes in body composition during neoadjuvant chemotherapy were recorded and compared with the incidence of hematological adverse events.<bold>Results: </bold>There was a significant correlation between the BIA-predicted skeletal muscle index and the computed tomography-measured skeletal muscle index (P = 0.004), while there was no significant correlation between the prognostic nutrition index and the BIA-predicted nutrition index. After the completion of 3 cycles of neoadjuvant chemotherapy, the skeletal muscle index showed a significant decrease (P = 0.016), while the total body fat mass (P = 0.025), body fat percentage (P = 0.013), and body mass index (P = 0.004) showed a significant increase (a tendency toward "sarcopenic obesity"). Patients who experienced grade 2-3 anemia during neoadjuvant chemotherapy showed a significantly lower increase in body mass index compared with patients who did not experience high-grade toxicities (P = 0.032).<bold>Conclusions: </bold>BIA could contribute to other methods of nutrition and muscle assessment for pretreatment risk stratification in patients with UC. Further study of a larger cohort is required to elucidate the clinical impact of changes in body composition during chemotherapy.
- Subjects
BIOELECTRIC impedance; TRANSITIONAL cell carcinoma; CACHEXIA; SARCOPENIA; ANTINEOPLASTIC agents; CANCER chemotherapy; ONCOLOGIC surgery; URINARY organ surgery; BODY composition; CANCER; COMBINED modality therapy; NUTRITIONAL assessment; RESEARCH funding; URINARY organs; RETROSPECTIVE studies; SKELETAL muscle
- Publication
Supportive Care in Cancer, 2018, Vol 26, Issue 4, p1077
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-017-3924-0