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- Title
Atrial Natriuretic Peptide Response Is Blunted in Patients with Acute Myocardial Infarction and Mild Left Ventricular Dysfunction.
- Authors
Derchi, Giorgio; Bellone, Pietro; Tommasini, Giorgio; Luisa Biorci, Maria; Randazzo, Matilde; Primarolo, Paola; Vecchio, Carlo
- Abstract
Neurohumoral parameters in 45 asymptomatic patients with acute myocardial infarction were measured. In patients with mild left ventricular dysfunction (ejection fraction < 45% and/or left ventricular end-diastolic pressure > 15 mm Hg), atrial natriuretic peptide levels differed significantly from those in patients with normal left ventricular function (127 ± 74pg/ml vs. 79 ± 71 pg/ml; p < 0.001). After stimulus an increase in atrial natriuretic peptide levels (79 ± 71 to 118 ± 86 pg/ml; p < 0.001) was found only in patients with normal hemodynamic parameters. These data show that in patients with left ventricular dysfunction, the atrial natriuretic system is activated; however, atrial natriuretic peptide response to stimulus is present only in patients with normal hemodynamics. Copyright © 1994 S. Karger AG, Basel
- Publication
Cardiology, 1994, Vol 84, Issue 2, p79
- ISSN
0008-6312
- Publication type
Article
- DOI
10.1159/000176525