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The impact of trauma relevant concentrations of prostaglandin E<sub>2</sub> on the anti-microbial activity of the innate immune system.
Published in:
Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1401185
By:
- Nicholson, Thomas;
- Belli, Antonio;
- Lord, Janet M.;
- Hazeldine, Jon
Publication type:
Article
Machine learning for the detection of early immunological markers as predictors of multi-organ dysfunction.
Published in:
Scientific Data, 2019, v. 6, n. 1, p. 1, doi. 10.1038/s41597-019-0337-6
By:
- Bravo-Merodio, Laura;
- Acharjee, Animesh;
- Hazeldine, Jon;
- Bentley, Conor;
- Foster, Mark;
- Gkoutos, Georgios V.;
- Lord, Janet M.
Publication type:
Article
Impact of plasma viscosity on microcirculatory flow after traumatic haemorrhagic shock: A prospective observational study.
Published in:
Clinical Hemorheology & Microcirculation, 2019, v. 71, n. 1, p. 71, doi. 10.3233/CH-180397
By:
- Naumann, David N.;
- Hazeldine, Jon;
- Bishop, Jon;
- Midwinter, Mark J.;
- Harrison, Paul;
- Nash, Gerard;
- Hutchings, Sam D.
Publication type:
Article
Integration of Metabolomic and Clinical Data Improves the Prediction of Intensive Care Unit Length of Stay Following Major Traumatic Injury.
Published in:
Metabolites (2218-1989), 2022, v. 12, n. 1, p. 29, doi. 10.3390/metabo12010029
By:
- Acharjee, Animesh;
- Hazeldine, Jon;
- Bazarova, Alina;
- Deenadayalu, Lavanya;
- Zhang, Jinkang;
- Bentley, Conor;
- Russ, Dominic;
- Lord, Janet M.;
- Gkoutos, Georgios V.;
- Young, Stephen P.;
- Foster, Mark A.
Publication type:
Article
Accelerated aging of skeletal muscle and the immune system in patients with chronic liver disease.
Published in:
Experimental & Molecular Medicine EMM, 2024, v. 56, n. 7, p. 1667, doi. 10.1038/s12276-024-01287-y
By:
- Nicholson, Thomas;
- Dhaliwal, Amritpal;
- Quinlan, Jonathan I.;
- Allen, Sophie L.;
- Williams, Felicity R.;
- Hazeldine, Jon;
- McGee, Kirsty C.;
- Sullivan, Jack;
- Breen, Leigh;
- Elsharkawy, Ahmed M.;
- Armstrong, Matthew J.;
- Jones, Simon W.;
- Greig, Carolyn A.;
- Lord, Janet M.
Publication type:
Article
Innate immunesenescence: underlying mechanisms and clinical relevance.
Published in:
Biogerontology, 2015, v. 16, n. 2, p. 187, doi. 10.1007/s10522-014-9514-3
By:
- Hazeldine, Jon;
- Lord, Janet
Publication type:
Article
Cyclin-Dependent Kinase 9 Activity Regulates Neutrophil Spontaneous Apoptosis.
Published in:
PLoS ONE, 2012, v. 7, n. 1, p. 1, doi. 10.1371/journal.pone.0030128
By:
- Wang, Keqing;
- Hampson, Peter;
- Hazeldine, Jon;
- Krystof, Vladimir;
- Strnad, Miroslav;
- Pechan, Paul;
- Lord, Janet M.
Publication type:
Article
Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia. A Pilot Randomized Controlled Clinical Trial.
Published in:
2019
By:
- Sapey, Elizabeth;
- Patel, Jaimin M.;
- Greenwood, Hannah;
- Walton, Georgia M.;
- Grudzinska, Frances;
- Parekh, Dhruv;
- Mahida, Rahul Y.;
- Dancer, Rachel C. A.;
- Lugg, Sebastian T.;
- Howells, Philip A.;
- Hazeldine, Jon;
- Newby, Paul;
- Scott, Aaron;
- Nightingale, Peter;
- Hill, Adam T.;
- Thickett, David R.
Publication type:
journal article
Pulmonary Infections in the Elderly Lead to Impaired Neutrophil Targeting, Which Is Improved by Simvastatin.
Published in:
2017
By:
- Sapey, Elizabeth;
- Patel, Jaimin M.;
- Greenwood, Hannah L.;
- Walton, Georgia M.;
- Hazeldine, Jon;
- Sadhra, Charendeep;
- Parekh, Dhruv;
- Dancer, Rachel C. A.;
- Nightingale, Peter;
- Lord, Janet M.;
- Thickett, David R.;
- Dancer, Rachel Ca
Publication type:
journal article
Traumatic Injury and Exposure to Mitochondrial-Derived Damage Associated Molecular Patterns Suppresses Neutrophil Extracellular Trap Formation.
Published in:
Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00685
By:
- Hazeldine, Jon;
- Dinsdale, Robert J.;
- Harrison, Paul;
- Lord, Janet M.
Publication type:
Article
The ultra-acute steroid response to traumatic injury: a cohort study.
Published in:
European Journal of Endocrinology, 2023, v. 188, n. 3, p. 290, doi. 10.1093/ejendo/lvad024
By:
- Bentley, Conor;
- Hazeldine, Jon;
- Bravo, Laura;
- Taylor, Angela E.;
- Gilligan, Lorna C.;
- Shaheen, Fozia;
- Acharjee, Animesh;
- Gkoutos, George;
- Foster, Mark A.;
- Arlt, Wiebke;
- Lord, Janet M.
Publication type:
Article
Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality.
Published in:
European Journal of Endocrinology, 2017, v. 176, n. 4, p. 471, doi. 10.1530/EJE-16-0969
By:
- Bancos, Irina;
- Hazeldine, Jon;
- Chortis, Vasileios;
- Hampson, Peter;
- Taylor, Angela E.;
- Lord, Janet M.;
- Arlt, Wiebke
Publication type:
Article
A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age.
Published in:
GeroScience, 2024, v. 46, n. 5, p. 4333, doi. 10.1007/s11357-024-01138-8
By:
- McGee, Kirsty C.;
- Sullivan, Jack;
- Hazeldine, Jon;
- Schmunk, Lisa J.;
- Martin-Herranz, Daniel E.;
- Jackson, Thomas;
- Lord, Janet M.
Publication type:
Article
The immune suppressive properties of damage associated molecular patterns in the setting of sterile traumatic injury.
Published in:
Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1239683
By:
- Horner, Emily;
- Lord, Janet M.;
- Hazeldine, Jon
Publication type:
Article
Dysfunctional neutrophil response in COVID-19 infection vary by subtype.
Published in:
Clinical Medicine, 2023, v. 23, p. s69, doi. 10.7861/clinmed.23-6-s69
By:
- Thein, Onn Shaun;
- Belchamber, Kylie;
- Hazeldine, Jon;
- Faniyi, Aduragbemi;
- Grudzinska, Frances;
- Hughes, Michael;
- Jasper, Alice;
- Kay Por Yip;
- Crowley, Louise;
- Lugg, Sebastian;
- Sapey, Elizabeth;
- Parekh, Dhruv;
- Thickett, David;
- Scott, Aaron
Publication type:
Article
Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets.
Published in:
Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.680134
By:
- Hazeldine, Jon;
- Lord, Janet M.
Publication type:
Article
Immunesenescence: A Predisposing Risk Factor for the Development of COVID-19?
Published in:
Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.573662
By:
- Hazeldine, Jon;
- Lord, Janet M.
Publication type:
Article
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis.
Published in:
Immunity & Ageing, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12979-022-00317-5
By:
- Foster, Mark A.;
- Bentley, Conor;
- Hazeldine, Jon;
- Acharjee, Animesh;
- Nahman, Ornit;
- Shen-Orr, Shai S.;
- Lord, Janet M.;
- Duggal, Niharika A.
Publication type:
Article
Heparin resistance in severe thermal injury: a prospective cohort study.
Published in:
Burns & Trauma, 2021, v. 9, p. 1, doi. 10.1093/burnst/tkab032
By:
- Cato, Liam D;
- Bailiff, Benjamin;
- Price, Joshua;
- Ermogeneous, Christos;
- Hazeldine, Jon;
- Lester, William;
- Lowe, Gillian;
- Wearn, Christopher;
- Bishop, Jonathan R B;
- Lord, Janet M;
- Moiemen, Naiem;
- Harrison, Paul
Publication type:
Article
Traumatic injury is associated with reduced deoxyribonuclease activity and dysregulation of the actin scavenging system.
Published in:
Burns & Trauma, 2021, v. 9, p. 1, doi. 10.1093/burnst/tkab001
By:
- Hazeldine, Jon;
- Dinsdale, Robert J;
- Naumann, David N;
- Acharjee, Animesh;
- Bishop, Jonathan R B;
- Lord, Janet M;
- Harrison, Paul
Publication type:
Article
Dysregulated Neutrophil Phenotype and Function in Hospitalised Non-ICU COVID-19 Pneumonia.
Published in:
Cells (2073-4409), 2022, v. 11, n. 18, p. N.PAG, doi. 10.3390/cells11182901
By:
- Belchamber, Kylie B. R.;
- Thein, Onn S.;
- Hazeldine, Jon;
- Grudzinska, Frances S.;
- Faniyi, Aduragbemi A.;
- Hughes, Michael J.;
- Jasper, Alice E.;
- Yip, Kay Por;
- Crowley, Louise E.;
- Lugg, Sebastian T.;
- Sapey, Elizabeth;
- Parekh, Dhruv;
- Thickett, David R.;
- Scott, Aaron
Publication type:
Article
Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study.
Published in:
2017
By:
- Hazeldine, Jon;
- Naumann, David N.;
- Toman, Emma;
- Davies, David;
- Bishop, Jonathan R. B.;
- Su, Zhangjie;
- Hampson, Peter;
- Dinsdale, Robert J.;
- Crombie, Nicholas;
- Duggal, Niharika Arora;
- Harrison, Paul;
- Belli, Antonio;
- Lord, Janet M.
Publication type:
journal article
Severe thermal and major traumatic injury results in elevated plasma concentrations of total heme that are associated with poor clinical outcomes and systemic immune suppression.
Published in:
Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1416820
By:
- Tullie, Sebastian;
- Nicholson, Thomas;
- Bishop, Jonathan R. B.;
- McGee, Kirsty C.;
- Asiri, Ali;
- Sullivan, Jack;
- Yung-Yi Chen;
- Sardeli, Amanda V.;
- Belli, Antonio;
- Harrison, Paul;
- Moiemen, Naiem S.;
- Lord, Janet M.;
- Hazeldine, Jon
Publication type:
Article
Circulating myeloid populations have prognostic utility in alcohol-related liver disease.
Published in:
Frontiers in Immunology, 2024, p. 01, doi. 10.3389/fimmu.2024.1330536
By:
- Khan, Reenam;
- Salman, Shees;
- Harford, Laura;
- Sheriff, Lozan;
- Hazeldine, Jon;
- Rajoriya, Neil;
- Newsome, Philip N.;
- Lalor, Patricia F.
Publication type:
Article
Traumatic brain injury and peripheral immune suppression: primer and prospectus.
Published in:
Frontiers in Neurology, 2015, v. 6, p. 1, doi. 10.3389/fneur.2015.00235
By:
- Hazeldine, Jon;
- Lord, Janet M.;
- Belli, Antonio;
- Clausen, Fredrik;
- Kobeissy, Firas H.
Publication type:
Article
IL-8 Induces Neutrophil Extracellular Trap Formation in Severe Thermal Injury.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 13, p. 7216, doi. 10.3390/ijms25137216
By:
- Asiri, Ali;
- Hazeldine, Jon;
- Moiemen, Naiem;
- Harrison, Paul
Publication type:
Article
Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals.
Published in:
Aging Cell, 2014, v. 13, n. 4, p. 690, doi. 10.1111/acel.12222
By:
- Hazeldine, Jon;
- Harris, Phillipa;
- Chapple, Iain L.;
- Grant, Melissa;
- Greenwood, Hannah;
- Livesey, Amy;
- Sapey, Elizabeth;
- Lord, Janet M.
Publication type:
Article
Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity.
Published in:
Aging Cell, 2012, v. 11, n. 5, p. 751, doi. 10.1111/j.1474-9726.2012.00839.x
By:
- Hazeldine, Jon;
- Hampson, Peter;
- Lord, Janet M.
Publication type:
Article
Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study.
Published in:
PLoS ONE, 2017, v. 12, n. 12, p. 1, doi. 10.1371/journal.pone.0189870
By:
- Naumann, David N.;
- Hazeldine, Jon;
- Dinsdale, Robert J.;
- Bishop, Jon R.;
- Midwinter, Mark J.;
- Harrison, Paul;
- Hutchings, Sam D.;
- Lord, Janet M.
Publication type:
Article
Changes in the pattern of plasma extracellular vesicles after severe trauma.
Published in:
PLoS ONE, 2017, v. 12, n. 8, p. 1, doi. 10.1371/journal.pone.0183640
By:
- Kuravi, Sahithi J.;
- Yates, Clara M.;
- Foster, Mark;
- Harrison, Paul;
- Hazeldine, Jon;
- Hampson, Peter;
- Watson, Chris;
- Belli, Antonio;
- Midwinter, Mark;
- Nash, Gerard B.
Publication type:
Article

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