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- Title
TAU PROTEIN AS GLIAL TUMORS MARKER: A RETROSPECTIVE STUDY.
- Authors
Abdulghany, Zaynab S.; Kareem, Noora M.; AbdulRahman, Imad M.
- Abstract
Tau is a known protein expressed in brain tissue. It is expressed in different neurological diseases like Huntington's and Alzheimer and also in different cancer types. Her2 protein is known to be a biomarker and prognostic factor in breast cancer and also expressed in different types of carcinoma like gastric, lung, salivary duct, ovarian and endometrial. To determine tau and Her2 protein expressions in different types of primary brain tumors and to assess the correlation between their expression and the grade of the tumor. 54 paraffin blocks of surgical specimen of different brain tumors had been reviewed, selected and categorized as glial, meningioma and pituitary tumors. Clinical details of all the cases were recorded from Immunohistochemistry department of Neurology Hospital in Baghdad/Iraq. Immunohistochemistry for tau and Her2 proteins were performed along with scoring. twenty men and 34 women were diagnosed and underwent surgery as having brain tumor: 30 cases were glial tissue, 22 cases were meningioma and 2 cases were pituitary. Tau protein distribution was as follows: 12 cases [22%] with 0 score, 24 cases [44%] were scored with + 1, 6 cases (11%) with +2 and 12 cases (22%) with +3 score. While Her2 protein expression was negatively scored in all cases. For the glial tumors a correlation between tau immunoreactivity and the grade of the tumors. This study found that tau protein is expressed in glial tumors and suggested that this protein could be a good biomarker for brain tumor classification and can be used as a confirmatory test for glial tumors diagnosis.
- Subjects
TAU proteins; TUMOR markers; PROTEIN expression; NEUROLOGICAL disorders; IMMUNOHISTOCHEMISTRY
- Publication
Plant Archives (09725210), 2019, Vol 19, Issue 2, p4453
- ISSN
0972-5210
- Publication type
Article