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- Title
Structures of Mec1/ATR kinase endogenously stimulated by different genotoxins.
- Authors
Zhang, Qingjun; Wang, Po; Wu, Tengwei; Zhang, Yueyue; Zheng, Zexuan; Zhou, Shangzhi; Qian, Dong; Wang, Xuejuan; Cai, Gang
- Abstract
In 2017, we reported the first cryo-EM reconstruction of intact Mec1-Ddc2 (the yeast homolog of ATR-ATRIP), which elucidated how the kinase activity of Mec1 is poised for catalysis by the inhibition of the PRD domain[4]. Both the HU and MMS activated ATR/Mec1 increasing kinase activity by 10-fold (Fig. Dear Editor, The ataxia-telangiectasia mutated (ATM) and ATM-Rad3-related (ATR) are apical kinases that orchestrate the multifaceted DNA damage response to a variety of insults and regulate genomic stability[1].
- Subjects
DOUBLE-strand DNA breaks
- Publication
Cell Discovery, 2022, Vol 8, Issue 1, p1
- ISSN
2056-5968
- Publication type
Article
- DOI
10.1038/s41421-022-00461-8