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- Title
Chronic Periodontitis and Immunity, Towards the Implementation of a Personalized Medicine: A Translational Research on Gene Single Nucleotide Polymorphisms (SNPs) Linked to Chronic Oral Dysbiosis in 96 Caucasian Patients.
- Authors
Inchingolo, Francesco; Martelli, Francesco Saverio; Gargiulo Isacco, Ciro; Borsani, Elisa; Cantore, Stefania; Corcioli, Fabiana; Boddi, Anna; Nguyễn, Kieu C.D.; De Vito, Danila; Aityan, Sergey K.; Pham, Van Hung; Dipalma, Gianna; Ballini, Andrea
- Abstract
Chronic periodontitis (CP) is a complex pathology with a significant impact worldwide causing bone loss. Oral dysbiosis is a highly inflammatory condition associated to a long-term insulting infection and represents an underestimated CP key factor associated with an imbalance of pro-inflammatory and anti-inflammatory gene responses. The presence of a single nucleotide polymorphisms (SNPs) in the promoter region of interleukin 10 (IL-10) gene −1082, −819, and −592 was a possible determinant cause. This translational research aimed to provide outcomes on the role of IL-10 gene expression in bone loss diseases in patients affected by CP. Caucasian patients (n = 96) affected by CP were recruited from the Italian population. The subgingival samples were collected using the Bacterial Periodontal Assessment by Biomolecular Diagnostic® and the characterization of a set of 15 bacterial DNA responsible of periodontitis was performed by real-time multiplex PCR. In addition, two viruses, Epstein–Barr Virus (EBV) and Herpes Simplex Virus 1 (HSV-1), and a pathogenic fungi (Candida albicans) were included as a part of our panel. Our results confirmed an existing association between IL-10 gene polymorphisms and polymorphism of tumor necrosis factor alpha (TNFα), interleukin 1α-β-RN (IL-1α-β-RN), collagen type-l alpha (COLIA1), and vitamin D receptor (VDRs) genes in CP. Further studies are needed to improve diagnosis and endorse more effective therapeutic procedures for periodontal disease.
- Subjects
SINGLE nucleotide polymorphisms; MEDICAL research; TRANSLATIONAL research; INDIVIDUALIZED medicine; VITAMIN D receptors
- Publication
Biomedicines, 2020, Vol 8, Issue 5, p115
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines8050115